TRADE NAME: GABA

Chemical Name: Gamma-aminobutryic acid

Type of Supplement: Cognitive Function

WHAT IT IS: As a neurotransmitter in the brain, GABA induces relaxation to counter excitation1.

HOW IT WORKS: GABA is formed from glutamate (an amino acid) and vitamin B6. Glutamic acid decarboxylate constitutes the necessary enzyme to synthesize GABA. It appears that once GABA is made, increases in the alpha-type waves of the brain occur, which produces an anti-anxiety and relaxation effect. GABA may also play an anti-seizure role because of its ability to induce inhibitory signals in the brain. Glutamine-containing foods and a ketogenic diet (which typically favors glutamine synthesis and acetate production, to which brain cells then convert to glutamine) promote GABA formation2. Anabolic steroids may modulate GABA receptors in the brain3.

PRIMARY EFFECTS: GABA is primarily used for those experiencing anxiety or sleeplessness (insomnia). It appears levels of GABA in the brain vary between the sexes.

EFFECTIVE DOSAGE LEVEL: Approximately 250 mg GABA taken three times per day.

SUPPLEMENT CONFLICTS: Those on prescription medication may want to check with an allied health professional before using high doses of GABA.

SIDE EFFECTS: None reported.